BackgroundLittle information is available as to the safety of midazolam when used as an oral sedative.AimTo evaluate the side effects and other adverse outcomes following use of oral midazolam for behaviour management in paediatric dentistry.DesignA review of published literature relating to the safety and side effects of oral midazolam for use in paediatric dental procedures was conducted. Both randomised controlled trials and non‐randomised studies were assessed. Reported side effects were recorded and classified as either significant or minor. The percentage prevalence of significant or minor side effects per episode of treatment was calculated.ResultsSixteen papers of randomised controlled trials met the inclusion criteria. None of the side effects recorded were considered as significant. Minor side effects were reported (n = 68, 14%), with nausea and vomiting being the most frequently recorded (n = 30, 6%). Eleven papers of non‐randomised studies were included. No significant side effects were recorded. Minor side effects were recorded (n = 157, 8%), with paradoxical reaction being the most common at 3.8%.ConclusionSignificant side effects associated with oral midazolam usage
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