Abstract Transglutaminase 2 ( TG 2) is a protein that modulates neuronal survival processes. Although TG 2 is primarily cytosolic, data have suggested the nuclear localization of TG 2 is strongly associated with neuronal viability. Depletion of TG 2 in neurons results in neurite retraction and loss of viability, which is likely due to a dysregulation in gene expression. To begin to understand how TG 2 regulates neuronal gene expression, chromatin immunoprecipitation was performed in neurons with TG 2 overexpression. The resulting genomic DNA was recovered and sequenced. Bioinformatics analyses revealed that a signature DNA motif was enriched in the TG 2 immunoprecipitated genomic DNA . In particular, this motif strongly mapped to a region proximate to
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