The underlying mechanisms of efferocytosis by fibroblasts were not well understood. We demonstrate that the engulfment of PKH67‐labeled (green) apoptotic cells by human primary fibroblasts (HPFs) requires the remodeling of the actin cytoskeleton labeled with tetramethylrhodamine‐B‐isothiocyanate‐conjugated phalloidin (red). Confocal microscopy imaging reveals the typical features of phagosome formation that ultimately results in the engulfment of the apoptotic cell in a membrane‐bound vacuole. The nuclei are stained with DAPI (blue).
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