ABSTRACT Background Carpal tunnel syndrome (CTS) is the most prevalent peripheral nerve entrapment disorders of the upper limb worldwide, making carpal tunnel release (CTR) one of the most frequently performed procedures. While CTR is typically successful, a small but important subset of patients may experience failure of the initial surgery, presenting with persistent, recurrent, or new symptoms that may necessitate re‐exploration. Case Report This case series details four patients who were referred to a single Plastic Surgeon in Melbourne Australia, with concerning new or persistent symptoms following initial CTR. For each patient, the primary CTR was indicated due to severe, unrelieved symptoms of CTS that were refractory to conservative treatment. Discussion CTR is generally a highly effective procedure with positive outcomes for most patients. However, in some cases, symptoms can remain unresolved or may even worsen postoperatively. Prompt identification and referra
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