Abstract Objectives There have been many attempts to compare Uniportal Video-Assisted Thoracic Surgery (UVATS) with Multiportal VATS (MVATS) for anatomic lung resection. A review is warranted to appreciate: what has been learnt about the relative benefits of the 2 approaches; what lessons have been learned by the process of comparing approaches; and whether such comparisons should influence surgical practice. Methods A narrative review and qualitative analysis of the literature pertaining to UVATS and especially to comparisons between UVATS and MVATS was conducted. Results The balance of currently published evidence suggests that UVATS offers the following when compared to MVATS: equivalent safety; similar or slightly better post-operative outcomes (especially in reducing pain); equivalent treatment outcomes for lung cancer (measured by lymph node yields and medium-term survival); and broadly similar learning curves. There has been a general trend for studies comparing U
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