Abstract Background The Singapore General Hospitals’ clinical biochemistry laboratory constantly reviews and optimizes its automated chemistry testing through workflow enhancements and advancement of technology. The laboratory had evaluated 11 urine chemistry analytes on a standalone Beckman Coulter DxC700AU in view of upgrading its existing Beckman Coulter AU680. Methods The laboratory evaluated the following urine chemistry analytes: urea, sodium, potassium, chloride, creatinine, total protein, calcium, inorganic phosphate, magnesium, amylase and uric acid. The parameters evaluated were: linearity, limit of detection (LOD), carryover, imprecision and patient comparison against the AU680. Linearity was verified by analyzing Validate-It linearity materials in triplicate, and assessed by generating linearity statistics using Analyze-It v2.03. LOD was verified by analyzing 20 replicates of a blank matrix (saline) and 20 replicates of a patient specimen with concentrations near the LOD. Carryover was verified by sequentially analyzing a low concentration sample in tr
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