Abstract Introduction Nissen sleeve gastrectomy (NSG) is a bariatric procedure based on the combination of 2 well-known surgical techniques (vertical sleeve gastrectomy and Nissen fundoplication). It was presented in 2016 by Nocca et al. as a means to prevent the major drawback of sleeve gastrectomy (SG)—post-SG gastroesophageal reflux disease (GERD) and associated complications, while preserving the advantages of SG in terms of weight loss and remission of obesity-related comorbidities. Methods We present the case of a 51 years-old female patient with a body mass index of 33.4 kg/m2 and complaints of acid reflux. She had a family history of gastric cancer (father at 50 years-old). Upper gastrointestinal endoscopy exhibited grade A esophagitis, a 6 mm hyperplasic polyp in the cardia and a 1.2 cm subepithelial lesion in the duodenum. Discussion Given the patient’s background—GERD symptoms and the need to maintain endoscopic surveillance of the stomach and duodenum, she un
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