Abstract A chest x-ray radiograph is still the global standard for diagnosing pneumonia and helps distinguish between bacterial and viral pneumonia. Despite several studies, radiologists and physicians still have trouble correctly diagnosing and classifying pneumonia without false negatives. Modern mathematical modeling and artificial intelligence could help to reduce false-negative rates and improve diagnostic accuracy. This research aims to create a novel and efficient multiclass machine learning framework for analyzing and classifying chest x-ray images on a graphics processing unit (GPU). Researchers initially applied a geometric augmentation using a positional transformation function to the original dataset to enhance the sample size and aid future transfer learning. Models with the best accuracy, area under the receiver operating characteristics (AUROC), F1 score, precision, recall, and specificity are chosen from a pool of nine state-of-the-art neural network models. The best-performing models are then retrained using an ensemble technique using depth-wise convolutions, demonstrating significant improvements over the baseline models employed in this research.
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