Abstract Noncommunicable diseases and cancer account for an increasing share of global morbidity and mortality, with a disproportionate burden borne by low- and middle-income countries. Interventional radiology (IR) and interventional oncology provide minimally invasive and potentially cost-effective therapies, yet access to these services remains highly unequal because of limitations in imaging infrastructure, trained personnel, and sustainable supply chains. This review synthesizes evidence from global IR initiatives and outlines a framework for sustainable, locally driven program development in resource-constrained settings. Structural barriers to IR implementation are examined, including infrastructure fragility, workforce shortages, and challenges in consumable procurement. Existing models from sub-Saharan Africa and Asia demonstrate feasible pathways to capacity building through locally anchored training pipelines, train-the-trainer approaches, and national or regional accreditation mechanisms that support workforce retention and institutional legitimacy. Strategies for supply chain adaptation, cost-conscious technology use, and equipment optimization are di
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