Objective: Databases bring together diverse information in neuroimaging and psychiatry. They usually aim for both size and diversity of measures. The present article outlines the potential insights from the first entirely standardized and centralized International Brain Database. Method: The database consists of data from over 1000 normal subjects (age range 6-70 years) and a growing number of age-matched patients with a psychiatric illness, acquired from seven laboratories (New York, Rhode Island, London, Holland, Adelaide, Melbourne and Sydney). It is an ‘integrative’ neuroimaging (electroencephalography (EEG), event-related potentials (ERP), structural and functional magnetic resonance imaging (sMRI, fMRI)), psychometric, demographic and genomic database. Results: The most notable relationships in normal controls thus far include (i) an association between grey matter volume and EEG alpha frequency in frontal regions; (ii) a systematic reduction with age in cortical arousal (EEG power), speed of processing (ERP components) and most aspects of cognitive function, particularly for >50 years; (iii) a greater cortical arousal in female versus m
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