AbstractBackground: In contrast to the immunosupressed patient population, the prevalence of fluconazole‐resistant strains ofCandida albicansamong healthy individuals has not been extensively studied.Methods: Candidaspecies were cultured form 50 healthy outpatients with clinical signs of oral candidiasis. Following one week of the recommended fluconazole regimen, post‐treatment cultures were obtained. Both pre‐ and post‐treatment yeasts were identified andin vitrosusceptibility testing was performed using the NCCLS M‐27A method. Strains were further differentiated using established cDNA probes.Results: Forty‐four patients (88%) had positiveC.albicanscultures prior to treatment. Antifungal susceptibility testing of these strains demonstrated noin vitroresistance to fluconazole. At post‐treatment evaluation, eight patients (18%) had persistent signs of infection and 10 patients (23%) had positiveCandidasp. cultures despite no clinical signs of infection. DNA analysis confirmed that the sameC. albicansstrain was present both in the pre‐treatment and the post‐treatment cultures.Conclusions: Our results showed that the presence of fluconazole‐resistant strains ofC.albicansdoes not appea
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