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Progress in research on digestive system oncology

Xianglin Yuan · Oncology and Translational Medicine · 2015

Xianglin Yuan, Professor of Oncology, Doctoral Supervisor, Deputy Director of the Oncology Department and Director of the Digestive System Oncology Department, Tongji Hospital, Tongji Medical College of HUST, China. Yuan discovered that CT/CC genotypes of the TGFbeta1 rs1982073: T869C gene were associated with a low risk of radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) treated with definitive radio(chemo)therapy and thus might serve as a reliable predictor of RP (Journal of Clinical Oncology, 2009; cited over 70 times). He indicated that genetic variations in PI3K-AKT-mTOR could predict brain metastasis in patients with NSCLC (Journal of Clinical Cancer Research, 2014). He also discovered that among the candidate genes involved in the TGF-β pathway, polymorphisms of SMAD3 appeared to be highly predictive of outcome in patients with lung adenocarcinoma after gefitinib treatment, especially in those with epidermal growth factor receptor mutations (Annals of Oncology, 2014). He has published about 30 articles found in the Science Citation Index (SCI) and has managed 3 items of the National Natural Science Foundation of China. H

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