Leucine‐rich repeat proteins of synapses

AbstractLeucine‐rich repeats (LRRs) are 20–29‐aa motifs that mediate protein–protein interactions and are present in a variety of membrane and cytoplasmic proteins. Many LRR proteins with neuronal functions have been reported. Here, we summarize an emerging group of synaptic LRR proteins, which includes densin‐180, Erbin, NGL, SALM, and LGI1. These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses. © 2007 Wiley‐Liss, Inc.