AbstractIn the recent past, there has been a burgeoning interest in targeting cytokines such as IL‐3 for specific disease conditions of bone such as rheumatoid arthritis and multiple myeloma. Unlike other cytokines, IL‐3 is a cytokine with a multilineage potential and broad spectrum of target cells and it plays a vital role in hematopoiesis. Due to its common receptor subunit, the action of IL‐3 shows functional redundancy with other cytokines such as the granulocyte‐macrophage colony‐stimulating factor and IL‐5. IL‐3 has been successfully used in ameliorating radiation‐induced bone marrow aplasia and similar conditions. However, the role of IL‐3 in bone cells has not been fully unraveled yet; therefore, the aim of this overview is to present the effects of IL‐3 in bone with a special emphasis on osteoclasts and osteoblasts in a concise manner.
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