Abstract The active vitamin D metabolite 1,25‐dihydroxyvitamin D 3 [1,25‐D 3 ] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on the immune system. The sterol inhibits lymphocyte proliferation and immunoglobulin production in a dose‐dependent fashion. At a molecular level, 1,25‐D 3 inhibits the accumulation of mRNA for IL‐2, IFN‐γ, and GM‐CSF. At a cellular level, the hormone interferes with T helper cell (T h ) function, reducing T h ‐induction of immunoglobulin production by B cells and inhibiting the passive transfer of cellular immunity by T h ‐clones in vivo. The sterol promotes suppressor cell activity and inhibits the generation of cytotoxic and NK cells. Class II antigen expression on lymphocytes and monocytes is also a
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