AbstractExperimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor‐induced osteolysis, tumor itself, and production of nociceptive mediators in the bone‐tumor microenvironment. J. Cell. Biochem. © 2005 Wiley‐Liss, Inc.
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