RNT‐1 regulation in <i>C. elegans</i>

AbstractRUNXs are important transcription factors, which are involved in animal development and human carcinogenesis. RNT‐1, the only homologue of RUNXs, in Caenorhabditis elegans (C. elegans) has been identified and viable mutant animals of rnt‐1 gene have been isolated and characterized recently. Genetic analyses using rnt‐1 mutants have shown that RNT‐1 is regulated by TGFβ‐ and Wnt‐signaling pathways in the body size regulation and male tail development. Here, we review our current understanding of RNT‐1 functions in these signaling pathways. Furthermore, future prospects of RNT‐1 and BRO‐1 studies in C. elegans are discussed in this review. © 2005 Wiley‐Liss, Inc.