AbstractCardiologists must become more involved in discussing and recommending hormone replacement in postmenopausal women with established coronary artery disease, and those individuals at high risk of coronary events. A large amount of epidemiologic and observational data, as well as new research in vascular biology, strongly support the benefits of estrogen on the development and progression of coronary atherosclerosis. While breast and uterine cancer are valid concerns, selected high‐risk women with and without established coronary disease should be counseled by an informed cardiologist to consider hormone replacement therapy.
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