ABSTRACT Due to its biodiversity, traditional medicine has been recognized worldwide for centuries and continues to affect the development of complementary and alternative therapies. A wide variety of spices, herbs, and trees are known for their curative effects. Chili pepper (Ch‐p), a spice‐utilizing fruit, is rich in natural medicinally bioactive compounds, such as flavonoids, capsaicinoids, and many other phytochemicals and phytonutrients. Operating in synergy and consortium, these compounds demonstrate their functionality, in comparison to lonely treatment, as active agents in handling many disorders. These may include abnormal coagulation, oxidative stress, obesity, diabetes, inflammation, cancer, and microbe‐inducing diseases. Recently, capsaicinoids, particularly capsaicin, have been shown to manage the symptoms of significant viral diseases, including COVID‐19. Capsaicin also has the potential to be an effective anesthetic agent and enables Ch‐p to be expandedly employed as a topical preparation in relieving pain as well. The phytochemicals of Ch‐p are not only beneficial and inexpensive phyto‐alternatives in disease management, but they can also be used a
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