A photomicrograph of a cultured human cell showing the subcellular distribution of the L334R variant of karyopherin‐α3, which causes hereditary spastic paraplegia. Karyopherin‐α3, a nuclear transport receptor that mediates trafficking of proteins between the cell cytoplasm and nucleus, normally resides almost exclusively in nuclei (labeled blue), while the disease‐associated L334R variant (green) exhibits increased levels within the cytoplasm (stained red with tubulin antibodies). For more details see paper in this issue by Schob et al. (pp. 738–750).
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