A laser speckle contrast image showing blood flow in the face of a migraineur who had received an infusion of pramlinitide, an agonist for amylin receptors. Amylin is a peptide in the same family as CGRP, with which it shares agonist activity at the AMY1 receptor. Amylin can also provoke migraine‐like attacks, suggesting that an dual amylin‐CGRP antagonist may be effective for migraine. See Ghanizada et al. (pp. 1157–1171) in this issue.
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