A set of illustrations showing different types of axonal swellings encountered in normal appearing white matter, but indicative of axonal injury in brains of subjects with multiple sclerosis. The upper row shows a normal appearing axon immunostained red for neurofilaments to show the axon and green for proteolipid protein to show the myelin sheath. The second row shows blistering of the myelin sheath, the third row illustrates a swollen axon bleb, and the lowest row demonstrates an axon that has been disrupted. For explanation see Luchicchi et al. pages 711–725, in this issue.
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