A fluorescence photomicrograph of a section from the brain of an E17.5 mouse embryo, showing the distribution of cells labeled for CTIP2 (red) and TBR1 (green), genetic markers that label neurons in the deeper layers (V‐VI) of the developing cerebral cortex in an animal that expresses a mutation of the PIK3R2 gene that leads to megalencephaly and polymicrogyria in humans. The brains of the mutant mice are also enlarged with a mild lamination defect in the deeper layers due to enlarged, but not more, neurons. See Shi et al., pp. 1077–1094 in this issue for details.
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