Cover image: RASopathy genes and the role of their encoded proteins in the RAS‐MAPK signaling cascades. Cartoon lists the genes implicated in RASopathies and their year of discovery. Genes requiring further clinical delineation and/or functional validation in the context of the RASopathies are shown in red. Milestones linked to these discoveries are also reported. D and R indicate dominant and recessive, respectively. Below the figure of gene discovery timeline, the RAS‐MAPK signaling cascade showing the signal flow through the pathway (black arrows), together with the proteins positively (blue) and negatively (red) controlling the cascade, is presented. P and Ub indicate phosphorylation and ubiquitination, respectively. For further explanations see Figure 1 legend from paper by Tartaglia et al. (present issue). Image also shows pictures of some individuals affected by RASopathies. image
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