AbstractThis article reviews the performance of first trimester screening for chromosomal anomalies using various combinations of ultrasound and maternal serum biochemical modalities. Detection rates in excess of 90% can be routinely achieved for Trisomy 21, Trisomy 13, Trisomy 18 using a combination of fetal nuchal translucency (NT) thickness and maternal serum free ß‐hCG and PAPP‐A at 11 + 0 to 13 + 6 weeks of gestation. © 2007 Wiley‐Liss, Inc.
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